News and Publications

News

BIO has announced that Young Therapeutics, LLC is one of 35 finalists for its third annual Start-Up Stadium event, taking place at the BIO International Convention from June 19th-22nd in San Diego, CA. In 2017. Applications were judged by experts with entrepreneurial, investment, start-up, economic development, capital formation, and academic backgrounds from both the public and private sectors. A second panel will be evaluating the finalists’ during live presentations at the BIO International Convention #BIOstartup2017 #BIO2017

 

 

Publications

Myristoylated protein kinase c epsilon peptide inhibitor exerts cardioprotective effects in rat and porcine cardiac ischemia reperfusion injury - a translational study
YT-001 Pig.pdf
Adobe Acrobat document [1'000.5 KB]
The effects of modulating eNOS activity and coupling in ischemia/reperfusion (I/R)
IR eNOS Activity.pdf
Adobe Acrobat document [377.4 KB]
Mechanisms related to the cardioprotective effects of protein kinase C epsilon (PKC ɛ) peptide activator or inhibitor in rat ischemia/reperfusion injury
CardioProtection PKCe Inhibition.pdf
Adobe Acrobat document [506.1 KB]

 

Lindon H. Young, Robert Barsotti, Israel Benjamin, Harsh Patel, Tejaswi Dittakavi, Qian Chen (2016). Comparing the Effects of Myristic Acid- and TAT- conjugated peptides to their native counterparts targeting intracellular pathways mediating myocardial ischemia/reperfusion injury and neutrophil superoxide release. Current Topics in Peptide and Protein Research 17: 83-89, 2016.

 

Qian Chen, Hung Pham, Manoj A. Jivani, Jovan S. Adams, Michael Dawley, Michael Hart, Simon Okewole, Lindon H. Young. PKC delta () Peptide Activator exerts anti-inflammation and cardioprotective effects. Medical Research Archives, 1(2), 1-22, 2015

 

Alexandra C. Lopez, Qian Chen, Brittany L. Deiling, Edward S. Iames, Robert Barsotti, and Lindon H. Young. The Effects of Modulating Endothelial Nitric Oxide Synthase (eNOS) Activity and Coupling in Extracorporeal Shock Wave Lithotripsy (ESWL). Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 58-59, 2013.

 

Amber N. Koon, Maria A. Kern, Lindon H. Young, Edward Iames, Robert Barsotti, and Qian Chen. Effects of Modulating eNOS Activity on Leukocyte-endothelial Interactions in Rat Mesenteric Postcapillary Venules. Proceedings of the 23rd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 38-39, 2013.

 

Kerry-Anne A. Perkins, Sailesh Pershad, Qian Chen, Sloane McGraw, Jovan S. Adams, Christopher Zambrano, Samuel Krass, Jeffrey Emrich, Brandon Bell, Michael Iyamu, Catherine Prince, Helen Kay, Jane Chun-wen Teng and Lindon H. Young. The effects of modulating eNOS activity and coupling in ischemia/reperfusion (I/R). Naunyn-Schmiedeberg’s Arch of Pharmacol 385(1):27-38, 2012.

 

Teng JC, Kay H, Chen Q, Adams J, Zambrano C, Krass S, Grilli C, Guglielmello G, Bell A, Young LH. Mechanisms related to cardioprotective effects of protein Kinase C epsilon peptide activator (PKC +) and inhibitor (PKC -) in rat ischemia/reperfusion injury. Naunyn-Schmiedeberg’s Archives of Pharmacology 378(1):1-15 2008.

 

Phillipson A, Peterman EE, Taormina II P, Harvey M, Brue RJ, Atkinson N, Omiyi D, Chukwu U and Young LH. Protein kinase C zeta inhibition exerts cardioprotective effects in ischemia/reperfusion injury. Am J Physiol Heart Circ Physiol 289: H898-H907, 2005.

 

Omiyi D, Brue R, Taormina P, Harvey M, Atkinson NK and Young, LH. Protein kinase C beta II (PKC-βII) peptide inhibitor exerts cardioprotection in polymorphonuclear leukocyte (PMNs) induced ischemia/reperfusion (I/R) injury. J Pharmacol Exp Thera 314: 542-551, 2005.

 

Peterman EE, Taormina II P, Harvey M and Young LH. Gö 6983 exerts cardioprotective

effects in myocardial ischemia/reperfusion. J Cardiovasc Pharmacol 43: 645-656, 2004.

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